Gene-Expression Analysis Identifies IGFBP2 Dysregulation in Dental Pulp Cells From Human Cleidocranial Dysplasia
نویسندگان
چکیده
منابع مشابه
Transdifferentiation of Human Dental Pulp Stem Cells Into Oligoprogenitor Cells
Introduction: The nerve fibers in central nervous system are surrounded by myelin sheet which is formed by oligodendrocytes. Cell therapy based on oligodendrocytes and their precursors transplantation can hold a promising alternative treatment for myelin sheet repair in demyelinating diseases. Methods: Human Dental Pulp Stem Cells (hDPSCs) are noninvasive, autologous and easy available s...
متن کاملAnalysis of Senescence-Related Differentiation Potentials and Gene Expression Profiles in Human Dental Pulp Stem Cells.
INTRODUCTION Dental pulp stem cell (DPSC)-mediated dental pulp regeneration is considered a promising method for the treatment of deep caries with pulpitis. However, mesenchymal stem cell (MSC) senescence is an adverse factor from the perspective of cell-based therapies. In this study, we investigated the characteristics and expression profiles of DPSCs from young and old donors. METHODS DPSC...
متن کاملSkeletal and Dental Features of Cleidocranial Dysplasia
1 Department of Oral Medicine and Radiology, A B Shetty Memorial Institute of Dental Sciences Nitte University, Deralakatte, Mangalore-575 018, Karnataka, India. 2 MAHE Institute of Dental Sciences and Hospital, Chalakkara, Pallor, Manipal University, Manipal, Karnataka, India. 3 Department of Periodontics, A B Shetty Memorial Institute of Dental Sciences, Nitte University, Deralakatte, Mangalo...
متن کاملAnalysis of gene expression during odontogenic differentiation of cultured human dental pulp cells
OBJECTIVES We analyzed gene-expression profiles after 14 day odontogenic induction of human dental pulp cells (DPCs) using a DNA microarray and sought candidate genes possibly associated with mineralization. MATERIALS AND METHODS Induced human dental pulp cells were obtained by culturing DPCs in odontogenic induction medium (OM) for 14 day. Cells exposed to normal culture medium were used as ...
متن کاملComplex dental anomalies in a belatedly diagnosed cleidocranial dysplasia patient
Cleidocranial dysplasia (CCD) is a rare congenital disorder, typically characterized by persistently open skull sutures, aplastic or hypoplastic clavicles, and supernumerary teeth. Mutations in the gene encoding the runt-related transcription factor 2 (RUNX2) protein are responsible for approximately two thirds of CCD patients. We report a 20-year-old CCD patient presenting not only with typica...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Genetics
سال: 2018
ISSN: 1664-8021
DOI: 10.3389/fgene.2018.00178